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KMID : 0616619950010010367
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Journal of Soonchunhyang Medical College
1995 Volume.1 No. 1 p.367 ~ p.377
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Electron Microscopic Study on Vibrio vulnificus Infection in Cultured Endothelial Cells
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Abstract
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To elucidate the pathogenesis of hematogenous V. vulnW7cus infection in fulminant Vibrio septicemia, V. vukocus was inoculated in cultured human endothelial cells.
Endothelial cells were prepared from the umbilical vein that was freshly isolated from human umbilical cord
The ultrastructural change demonstrated a sequence of steps which occurred with V. vulnfcus invasion of the cultured human endothelial cells and the results were follows.
1. The cytopathic effect was appeared at the initial attachment stage of V. vulnOlcus infection. The characteristic of cytopathic effect were the formation of severe vacuolization and cell lysis.
2. The present study demonstrates that the reason of destruction of endothelial cell was caused by the production of toxic products than the growth of V. vukocus.
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